Which of the following describes how the dose-response curve informs the selection of the recommended Phase 2/3 dose?

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The dose-response curve shows how patient response changes as the dose increases, and it is used to pick the Phase 2/3 dose by identifying where you achieve meaningful efficacy without crossing into unacceptable safety risk. It highlights the minimum dose that produces the desired effect (the lowest effective dose) and the point where increasing the dose yields little extra benefit but increases adverse effects (the upper bound). The goal is to find a dose within that window that delivers near-maximal efficacy while maintaining an acceptable safety profile, often near the plateau where additional dose provides little added benefit. This approach accounts for variability between patients and helps balance efficacy with tolerability, rather than focusing solely on maximum efficacy or ignoring safety.