Which ADME stage describes the dispersion of a drug from the bloodstream into body tissues?

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Multiple Choice

Which ADME stage describes the dispersion of a drug from the bloodstream into body tissues?

Distribution describes the movement of a drug from the bloodstream into body tissues. After a drug enters circulation, it spreads to tissues based on blood flow, capillary permeability, and the drug’s chemical properties. Lipophilic drugs cross membranes more readily and can accumulate in fat or deeply perfused organs like the liver, kidneys, and brain. How much drug is free to move into tissues is also influenced by binding to plasma proteins. By contrast, absorption is about entering the blood from the administration site, metabolism is the chemical modification often in the liver, and excretion is the removal of drug and metabolites from the body.

Distribution describes the movement of a drug from the bloodstream into body tissues. After a drug enters circulation, it spreads to tissues based on blood flow, capillary permeability, and the drug’s chemical properties. Lipophilic drugs cross membranes more readily and can accumulate in fat or deeply perfused organs like the liver, kidneys, and brain. How much drug is free to move into tissues is also influenced by binding to plasma proteins. By contrast, absorption is about entering the blood from the administration site, metabolism is the chemical modification often in the liver, and excretion is the removal of drug and metabolites from the body.

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