What steps should be taken to check if two medicines can be used together?

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Verifying potential drug–drug interactions with a current, evidence-based reference is essential before combining medicines. Open the Australian Medicines Handbook, go to the Interactions section, enter both medicines, and review the reported interaction and its severity. Then follow the guidance provided—if there’s a major interaction, avoid the combination; if possible, choose alternatives or plan monitoring and dose adjustments. This approach relies on up-to-date, curated safety data rather than memory, and it considers safety and effectiveness rather than factors like who makes the medicines or reimbursement lists.